Research Advance on In Vitro Generation of Human Hematopoietic Stem Cells for Transplantation--Review.
10.7534/j.issn.1009-2137.2020.01.053
- Author:
Qing-Yun ZHANG
1
;
Fang DONG
1
;
Hideo EMA
2
Author Information
1. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China,Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China.
2. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China,Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China,E-mail: hema@ihcams.ac.cn.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2020;28(1):320-324
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Currently, hematopoietic stem cell (HSC) transplantation is widely used in the therapy of hematological malignancies, non-malignant refractory anemia, genetic diseases and certain tumors with satisfactory therapeutic efficacy. HSC sources used for transplantation include bone marrow, mobilized peripheral blood and neonate umbilical cord blood. However, for many patients, sufficient number of human leukocyte antigen (HLA) -matched HSC cannot be found for transplantation, because the number of HSC in these tissues is small and HLA-identical donors are rare. Thus, in vitro generation of HSC has recently been focused. At present, the origin of HSC is hPSC, including hESC and hiPSC, which is worth to be the new origin of HSC transplantation. However, to generate functional hematopoietic stem cells which have efficient multi-lineage differentiation and in vivo engraftment potentials still is a big challenge to be confronted. In this review, the recent technical progress in HSC generation is summarizd, and the problems to be solved and new challenges to be confronted were discussed.
