Epigenetic Regulation and Epigenomic Landscape in Normal Physiological Hematopoiesis--Editorial.
10.19746/j.cnki.issn.1009-2137.2019.06.001
- Author:
Zi-Xing CHEN
1
,
2
Author Information
1. Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University
2. Ministry of Health Key Laboratory of Thrombosis and Hemostasis, Suzhou 215006, Jiangsu Province, China E-mail: szchenzx@263.net.
- Publication Type:Editorial
- MeSH:
Cell Differentiation;
Epigenesis, Genetic;
Epigenomics;
Hematopoiesis;
Hematopoietic Stem Cells
- From:
Journal of Experimental Hematology
2019;27(6):1711-1716
- CountryChina
- Language:Chinese
-
Abstract:
Abstract The physiological hematopoiesis depends on the programmed expression of a series of gene regulated by mechanisms at various levels. Currently, the epigenetic regulation has been considered as the most important mechanism during hematopoietic differentiation, resulting in a specific epigenomic landscape in the hematopoietic stem/progenitor cells. We try to concisely review the epigenetic mechanisms, including the genomic methylation, the histone modifications and the expression profiles of noncoding RNA, illustrating briefly the differentiation from the hematopoietic stem/progenitor cells to to the erythroid, myeloid and lymphoid cells.
