Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis.
10.1016/S1875-5364(19)30109-8
- Author:
Yi LING
1
,
2
;
Lin-Lin TENG
1
,
3
,
4
;
Juan HUA
1
,
2
;
De-Sen LI
1
,
3
,
4
;
Shi-Hong LUO
1
,
2
;
Yan-Chun LIU
1
,
2
;
Yan LIU
1
,
5
;
Sheng-Hong LI
1
,
6
Author Information
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
3. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
4. University of Chinese Academy of Sciences, Beijing 100049, China.
5. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: liuyan@mail.kib.ac.cn.
6. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: shli@mail.kib.ac.cn.
- Publication Type:Journal Article
- Keywords:
Antilipemic agent;
Caenorhabditis elegans;
Fat accumulation;
Fatty acid biosynthesis;
Leucosceptroid B;
Leucosceptrum canum;
Sesterterpenoid
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):892-899
- CountryChina
- Language:English
-
Abstract:
Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis elegans. Furthermore, leucosceptroid B was found to reduce fat storage, and downregulate the expression of two stearoyl-CoA desaturase (SCD) genes fat-6 and fat-7, and a fatty acid elongase gene elo-2 in wild-type C. elegans. In addition, leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6; fat-7 double mutant. These findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6, fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty acid. These findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents.
