Four new corynanthe-type alkaloids from the roots of Alstonia scholaris.
10.1016/S1875-5364(19)30113-X
- Author:
Jian ZHANG
1
;
Hua LI
2
;
Yong LI
1
;
Zi-Wei LI
1
;
Chen-Chen SANG
1
;
Mei-Hua GAO
2
;
Dong-Mei ZHANG
1
;
Xiao-Qi ZHANG
3
;
Wen-Cai YE
4
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China.
2. Chinese Patent Medicine Department, Guangdong Institute for Drug Control, Guangzhou 510663, China.
3. Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: xqzhang74@hotmail.com.
4. Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: chywc@aliyun.com.
- Publication Type:Journal Article
- Keywords:
Alstonia scholaris;
Apocynaceae;
Corynanthe-type alkaloids;
Vasorelaxant activity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):918-923
- CountryChina
- Language:English
-
Abstract:
Four new corynanthe-type alkaloids, meloslines C-F (1-4), together with four known ones (5-8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.
