Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla.
10.1016/S1875-5364(19)30115-3
- Author:
Yue WANG
1
;
Qing-Lan GUO
1
;
Ruo-Fei LI
1
;
Cheng-Bo XU
1
;
Cheng-Gen ZHU
1
;
Jian-Gong SHI
2
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: shijg@imm.ac.cn.
- Publication Type:Journal Article
- Keywords:
Folate derivative;
Folate metabolism.;
Rubiaceae;
Uncaria rhynchophylla;
Uncarophyllofolic acid
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):928-934
- CountryChina
- Language:English
-
Abstract:
Two new folate-derived analogues, named uncarophyllofolic acids A (1) and B (2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem (Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey's derivatization, along with comparison of their specific rotation and Cotton effect (CE) data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway of 1 and 2, associating to folate metabolism and the previously reported orychophragines A-C from Orychophragmus violaceus, is discussed.
