Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana.
10.1016/S1875-5364(19)30118-9
- Author:
Yuan WANG
1
;
Jing LIN
1
;
Qi WANG
1
;
Kun SHANG
1
;
De-Bing PU
1
;
Rui-Han ZHANG
1
;
Xiao-Li LI
1
;
Xiao-Chang DAI
1
;
Xing-Jie ZHANG
2
;
Wei-Lie XIAO
3
Author Information
1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
2. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: zhangxj@ynu.edu.cn.
3. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: xiaoweilie@ynu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory activity;
Callicarpa cathayana;
Clerodane diterpenoids;
Nitric oxide
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):953-962
- CountryChina
- Language:English
-
Abstract:
Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A-F (1-6), together with seven analogues (7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
