Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces.
10.1016/S1875-5364(19)30121-9
- Author:
Lei WANG
1
,
2
;
Li WANG
1
,
3
;
Zhi ZHOU
1
,
3
,
4
;
Yong-Jiang WANG
1
,
3
;
Jian-Ping HUANG
5
;
Ya-Tuan MA
6
;
Yang LIU
7
;
Sheng-Xiong HUANG
8
Author Information
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2. College of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Yangling 712100, China.
3. Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China.
4. Research Center, Chengdu Medical College, Chengdu 610500, China
5. State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
6. College of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Yangling 712100, China.
7. Research Center, Chengdu Medical College, Chengdu 610500, China.
8. State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: sxhuang@mail.kib.ac.cn.
- Publication Type:Journal Article
- Keywords:
Angucyclinones;
Benz[a]anthracenes;
Immunosuppressive activity;
Natural products;
Streptomyces
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):982-987
- CountryChina
- Language:English
-
Abstract:
Cangumycins A-F (1-6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B (2) and E (5) exhibit potent immunosuppressive activity (IC 8.1 and 2.7 μmol·L, respectively) against human T cell proliferation at a non-cytotoxic concentration.
