Healing of Injury of Meniscus Using Fibrin Glue and Meniscal Cell in Rabbit Model.
- Author:
Sun Mi SON
1
;
Jae Sun LEE
;
Cha Young CHOI
;
Jong Woong PARK
;
Byung Soo KIM
;
Jung Ho PARK
Author Information
1. Department of Chemical Engineering, Hanyang University, Seoul, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Meniscal cell;
Fibroblast;
Fibrocartilagenous cell;
Meniscus injury;
Fibrin glue
- MeSH:
Cell Transplantation;
Cells, Cultured;
Fibrin Tissue Adhesive*;
Fibrin*;
Fibroblasts;
Knee Joint;
Menisci, Tibial;
Regeneration;
Transplants
- From:Journal of Korean Orthopaedic Research Society
2003;6(2):265-273
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We attempt to heal the defect of meniscus using fibrin glue and allogenic meniscal cells in rabbit. MATERIALS AND METHODS: Meniscal cells were isolated from medial meniscus of knee joint of rabbit and cultured and expanded in vitro. The mixture of fibrin glue and meniscal cells implanted to the defect of rabbit meniscus. Examination of gross morphology, histological and immunohistochemical staining of retrieved specimens were performed at 3 and 6 weeks. RESULTS: Cultured cells uniformly displayed an elongated, fibroblastic and fibrocartilagenous morphology. The histological and immunohistochemical analysis revealed regeneration of meniscal tissue at the defect site. CONCLUSION: Meniscal cell transplantation with fibrin glue resulted in the regeneration of meniscus tissue successfully in rabbit model. This approach could be applied for treatment of meniscus injury.
