An Association Study of Apolipoprotein E Gene Polymorphism and Cataracts.
10.3341/jkos.2011.52.4.420
- Author:
Mijung CHI
1
;
Jung Soo IM
;
Hae Jung PAIK
Author Information
1. Department of Ophthalmology, Gachon University of Medicine and Science, Incheon, Korea. hjpaik@gilhospital.com
- Publication Type:Original Article
- Keywords:
Apolipoprotein E;
Cataract;
Gene polymorphism
- MeSH:
Adult;
Alleles;
Apolipoprotein E2;
Apolipoproteins;
Apolipoproteins E;
Cataract;
Eye;
Genotype;
Humans;
Korea;
Logistic Models;
Odds Ratio;
Polymerase Chain Reaction;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2011;52(4):420-428
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the association of apolipoprotein E (APOE) polymorphism and cataracts in the Korean population. METHODS: The present research included participants from a population-based study in Incheon, Korea. A sample of 126 adults genotyped for polymorphisms of APOE underwent a medical interview, an eye examination which included visual acuity testing, slitlamp cataract evaluation and fundus examination. The APOE polymorphism was determined using a polymerase chain reaction method. RESULTS: Eighty-eight participants (69.8%) were diagnosed with cataracts or had undergone cataract surgery in 1 or both eyes, and 38 participants (30.2%) demonstrated no signs of cataract. The frequencies of the APOE genotypes and alleles were not significantly different from the cataract and the control group. APOE epsilon2 carriers were less likely to have cataracts than non-epsilon2 carriers with an odds ratio of 0.367 which was almost statistically significant with the multiple logistic regression analysis (p = 0.052). CONCLUSIONS: There was no significant correlation of APOE genotype and cataracts. However, a slight negative association of APOE epsilon2 and cataracts were found in the Korean population.
