Research progress on mechanism in adaptation of hemoglobin to plateau hypoxia
- Author:
Xue LI
1
,
2
;
Wenbin LI
3
;
Shilan FENG
4
;
Rong WANG
1
,
2
Author Information
1. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
2. Key Laboratory of the Plateau Medicine, the 940 th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
3. Key Laboratory of the Plateau Medicine, the 940 th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
4. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
- From:
Journal of Zhejiang University. Medical sciences
2019;48(6):674-681
- CountryChina
- Language:Chinese
-
Abstract:
Low oxygen partial pressure is the main cause of acute mountain sickness.Hemoglobin plays a crucial physiological role in the binding, utilization, transportation and release of oxygen in the body. To increase the capacity of oxygen binding of hemoglobin or the capacity of oxygen supply in tissues can help alleviate altitude sickness. However, increasing hemoglobin content has certain limitations. Using techniques from molecular biology, researchers are looking for endogenous or exogenous substances that can regulate the conformation of hemoglobin to increase oxygen uptake in the alveoli, or the availability of alveolar oxygen in the tissues. At present, the research on allosteric modulators to improve the affinity of hemoglobin has made some progress, and research on applying this mechanism to plateau hypoxia is also underway. This article reviews the relationship between hemoglobin and hypoxia, the structure of hemoglobin and the role of various allosteric modulators in hypoxia, which would provide information for finding new substances regulating the conformation of hemoglobin.
