Research progress on the effects of plateau hypoxia on blood-brain barrier structure and drug permeability

Author: Yidan DING ^{1
,

2} ; Wenbin LI ³ ; Rong WANG ^{1
,

2} ; Jianchun ZHANG ⁴
Author Information

1. Key Laboratory of Plateau Environmental Damage Prevention, the 940 th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
2. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
3. Key Laboratory of Plateau Environmental Damage Prevention, the 940 th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
4. Department of Pharmacy, First Hospital of Chinese People's Liberation Army, Lanzhou 730000, China
From: Journal of Zhejiang University. Medical sciences 2019;48(6):668-673
CountryChina
Language:Chinese
Abstract: Drugs for the treatment of central nervous system diseases need to enter the brain tissue through the blood-brain barrier to function. In high altitude hypoxic environment, there are changes in tight junction proteins of blood-brain barrier tissue structure, transporters in astrocytes and endothelial cells and ATP in endothelial cells; at the same time the permeability of the blood-brain barrier is increased. These changes are an important reference for rational drug use in patients with central nervous system disease in the plateau region. This article reviews the research progress on the effects of plateau hypoxia on the structure of the blood-brain barrier and related drug permeability.