Role of the Immunohistochemical Marker (Ki67) in Diagnosis and Classification of Hydatidiform Mole
- Author:
Hasan Abu Deka FF
- Publication Type:Journal Article
- Keywords:
Gestational trophoblastic disease, partial mole, complete mole, hydropic abortion
- From:
The International Medical Journal Malaysia
2019;18(3):136-142
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Since the hallmark of gestational trophoblastic disease is trophoblastic proliferation, Ki67
is regarded as the best marker in studying hydatidiform mole.This study was conducted to evaluate the role
of this proliferative marker in distinguishing among hydropic abortion, partial and complete hydatidiform
mole. Materials and methods: This is a cross sectional study involving the application of Ki67 on a total
of 90 histological samples of curetting materials from molar (partial and complete mole) and non molar
hydropic abortion belong to Iraqi females, so three study groups were created. Immunohistochemical
expression in villous cytotrophoblasts, syncytiotrophoblasts and stromal cells were recorded separately by
three independent observers and the results were correlated statically. Results: The mean number of
stained nuclei of villous cytotrophoblasts and stromal cells was the highest in complete mole and the lowest
in non molar hydropic abortion. There is a significant statistical relationship regarding Ki67 labeling index in
villous cytotrophoblasts between partial moles and hydropic abortion, complete mole and partial moles,
hydropic abortion and complete mole. Regarding Ki67 labelling index in villous stromal cells, a significant
statistical relationship achieved when the correlation done between partial mole and hydropic abortions,
hydropic abortion and complete mole, while a non significant statistical relationship was achieved if the
correlation done between partial and complete mole. All villous syncytiotrophoblasts showed negative
results. Conclusion: Ki-67 labeling index in villous cytotrophblastic cells are useful in separating between
partial moles and hydropic abortion, partial mole and complete mole, hydropic abortion and complete
mole. While Ki-67 labeling index in villous stromal cells is only useful in separating between partial moles
and hydropic abortion, hydropic abortion and complete mole.
- Full text:180317.pdf
