Proteomic Profiles of Young Adults with Acute Myocardial Infarction
- Author:
Mohamed Bakrim N
- Collective Name:Mohd Shah AS, Mohd. Shah ANS, A. Talib N , A.Rahman J, Muhamad Bunnori N
- Publication Type:Journal Article
- Keywords:
proteomic, young adults, myocardial infarction
- From:
The International Medical Journal Malaysia
2019;18(3):112-119
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Proteomic profiling is essential in understanding the pathophysiological process of
multifactorial diseases such as acute myocardial infarction (AMI). Despite the increasing incidence of AMI in
young adults, proteomic-based study focusing on young AMI remains limited. This study aimed to examine
the plasma proteomic profiles of young adults with AMI compared to control subjects. We also hope to
identify disease-specific protein biomarkers that contribute to the development of AMI in the young.
Methods: Pooled plasma protein from 10 AMI patients aged 18 to 45 years and 10 age, gender and race -
matched volunteers were separated using two-dimensional electrophoresis (2-DE). The spots proteins were
analysed using the PD Quest analysis software. The spots proteins that were found to have been expressed
differently between the two groups were identified by Matrix Assisted Laser Desorption/Ionization Time of
Flight (MALDI-TOF) Mass Spectrometry. Results: There were three differently expressed proteins namely
Apolipoprotein AI (Apo AI), Apolipoprotein AIV (Apo AIV) and Haptoglobin (p < 0.05). The expressions of these
proteins were found to be increased in young patients with AMI compared to control subjects. Conclusion:
The up regulation of Apo AI, Apo AIV and Haptoglobin in AMI patients indicate their important roles in the
development of atherosclerotic disease. Thus, Apo AI, Apo AIV and Haptoglobin are potential disease
biomarkers for young AMI.
- Full text:180314.pdf
