Periodic Assessment of Antenatal and Post Natal Serum Endothelin-1 (ET-1) and Nitric Oxide (NO) Levels in Hypertensive Disorders of Pregnancy (HDP)
- Author:
Hidayah I.
- Collective Name: Tariq A.R.a , N.A. Jamanib , Maizura M.Z.a
- Publication Type:Journal Article
- Keywords:
Hypertensive Disorders of Pregnancy (HDP), Endothelin-1 (ET-1), Nitric Oxide (NO), Persistent Endothelial Dysfunction
- From:
The International Medical Journal Malaysia
2019;18(2):101-106
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular
(CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a
potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO)
bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as
hypertension. The study aims to determine serial ET-1 and NO levels in patients with HDP and its role in
persistent endothelial dysfunction. Materials and Methods: Thirty-six pregnant women from the following
categories (i) normal pregnant women (Control) (ii) chronic hypertension during pregnancy (CH) and (iii)
pregnancy induced hypertension (PIH) participated in this study. Blood pressure indices measurements and
sample collection were done at antepartum (32 weeks) and postpartum (8 weeks and 12 weeks). ET-1 and
serum NO were measured using the Human ET-1 (Endothelin-1) ELISA Kit and Nitric Oxide (total) detection
kit respectively. Results: Serum ET-1 was significantly higher in patients with CH (55.3 pg/ml) and PIH (35.6
pg/ml) compared to Control (11.8 pg/ml) during antenatal until 3 months postpartum (CH 38.3 pg/ml, PIH
29.5 pg/ml, Control 1.9 pg/ml). This was accompanied by significantly lower levels of serum NO in HDP
patients. Conclusion: Persistently higher than normal levels of ET-1 and lower than normal levels of NO up to
3 months postpartum in patients with history of HDP indicate presence of persistent endothelial dysfunction
despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS
disease risk.
- Full text:180213.pdf
