Protective Effects of Orlistat on Lipid Profile, Cardiac Oxidative Stress Biomarkers and Histology in High-fat Diet-induced Obese Rats
- Author:
Othman ZA
- Collective Name:Wan Ghazali WS, Noordin L, Omar N, Mohd. Yusof NA , Mohamed M
- Publication Type:Journal Article
- Keywords:
orlistat, obesity, cardiovascular, lipid profile, oxidative stress
- From:
The International Medical Journal Malaysia
2019;18(2):23-28
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Orlistat is a widely used drug in treating obesity as it promotes weight reduction. The aim
of this study was to determine the protective effects of orlistat (10 mg/kg/day) on cardiovascular
parameters and oxidative stress biomarkers in high-fat diet (HFD)-induced obese rats. Methods: Twenty-four
male rats Sprague Dawley rats were divided into three groups and fed with normal diet (N), HFD and HFD
with orlistat (HFD+O). Orlistat was administered daily by oral gavage and after six weeks, all rats were
sacrificed. Results: Administration of orlistat along with HFD (HFD+O) has brought significant decreases in
Lee obesity index and LDL level compared to HFD group. Activities of cardiac superoxide dismutase (SOD),
glutathione peroxidase (GPx) and catalase (CAT) were significantly higher, whereas level of oxidised LDL was
significantly lower in HFD+O group compared to HFD group. HFD group had significantly higher necrotic patch
area in myocardium while minimal histological changes were seen in HFD+O group. Conclusion: This study
may suggest that administration of orlistat at 10 mg/kg/day for 6 weeks may have protective effects against
the changes on Lee obesity index, lipid profiles, cardiac oxidative stress biomarkers and histology of
myocardium in HFD-induced obese rats possibly through its hypolipidaemic and antioxidant actions.
- Full text:180203.pdf
