Function of vascular endothelial cells in retinal budding angiogenesis and its regulatory mechanism
10.3980/j.issn.1672-5123.2020.2.12
- VernacularTitle:血管内皮细胞在视网膜出芽式血管生成中的作用及其调控机制
- Author:
Mu-Di Yao
1
Author Information
1. Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
vessel endothelial cell;
Tip cell;
Stalk cell;
sprouting angiogenesis;
signal path;
endothelial metabolism;
regulatory mechanism
- From:
International Eye Science
2020;20(2):251-254
- CountryChina
- Language:Chinese
-
Abstract:
In the progress of retinal angiogenesis, sprouting angiogenesis plays an important role in retinal normal development and neovascular diseases. The structural and functional integrities of vascular endothelial cells are essential condition of sprouting angiogenesis. Vascular endothelial cells possess various subtypes, each of which plays a different role in sprouting angiogenesis. Many mechanisms participate in the regulation of endothelial cells under physiological and pathological conditions, such as biological signaling pathway, metabolism, immune inflammation and non-coding RNA. In this review, we provided a brief overview of the role and the related regulatory mechanisms of vascular endothelial cells in retinal sprouting angiogenesis.
- Full text:202002012.PDF
