A new carbazole alkaloid from the stems of Clausena lansium
10.16438/j.0513-4870.2019-0744
- VernacularTitle:从黄皮茎枝中分离到的一个新的咔唑生物碱
- Author:
Jie MA
1
;
Xing-yan SUN
1
;
Ying-da ZANG
1
;
Jian-zhou MENG
2
;
Chuang-jun LI
1
;
Jing-zhi YANG
1
;
Dong-ming ZHANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
italic>Clausena lansium (Lour.) Skeels;
chemical constituent;
carbazole alkaloid;
antimicrobial;
cytotoxicity
- From:
Acta Pharmaceutica Sinica
2020;55(1):110-112
- CountryChina
- Language:Chinese
-
Abstract:
A new carbazole alkaloid was isolated from the aqueous extract of the stems of Clausena lansium (Lour.) Skeels by various chromatographic methods, including HPD-100, PRP-512A, silica gel, and reverse phase C18. Its structure was determined by spectroscopic and chemical methods, including UV, IR, HR-ESI-MS, 1D/2DNMR and ECD. Compound 1, named as Claulamine F, showed no antimicrobial activity on Staphylococcus aureus, Escherichia coli or Pseudomonas aeruginosa. In addition, compound 1 exhibited no cytotoxicity on five kinds of cancer cells through MTT methods.
