The key to fine manufacturing of liquid polyphenol preparations: the principle of multi-precipitation with steady-state reconstruction
10.16438/j.0513-4870.2019-0567
- VernacularTitle:多酚类液体制剂精细制造关键: 多元沉淀形成原理与稳态重构
- Author:
Hao-zhou HUANG
1
;
Fei RAN
1
;
Jun-zhi LIN
2
;
Meng-qi LI
3
;
Wen-quan ZOU
4
;
San-hu FAN
5
;
Ming YANG
6
;
Run-chun XU
1
;
Li HAN
1
;
Ding-kun ZHANG
1
Author Information
1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of TCM, Chengdu 611137, China
2. Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
3. Sichuan Nursing Vocational College, Chengdu 610100, China
4. College of Chemistry, Sichuan University, Chengdu 610064, China
5. Sanajon Pharmaceutical Group, Chengdu 610000, China
6. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:Research Article
- Keywords:
polyphenol;
liquid preparation;
colloid;
fine manufacturing;
precipitation;
self-assembly
- From:
Acta Pharmaceutica Sinica
2020;55(1):45-53
- CountryChina
- Language:Chinese
-
Abstract:
Plant polyphenols have a wide range of pharmacological activities and application prospects. Liquid polyphenol preparations have special physical phases and complex chemical compositions, with problems such as poor stability and easy precipitation during production and marketing. Taking the multi-precipitation mechanism of plant polyphenol liquid preparations as an example,we discuss the chemistry and composition of the precipitation, how it forms, whether precipitationcan be controlled, and the interaction law of three precipitation approaches. An unstable mechanism model is proposed where hydrolyzed tannin hydrolysis and catechin non-enzymatic oxidative polymerization repeatedly induces associative colloid aggregation and precipitation. This study explains the complex physicochemical changes in polyphenol solutions and the microcosmic mechanism of instability in the induced system and proposes a steady state reconstruction of liquid polyphenol preparation consistent with the common law of precipitation and control. It has scientific significance for promoting the development and manufacture of high quality liquid polyphenol preparations.
