Acute pancreatitis and epigenetic regulation mechanisms
10.3969/j.issn.1001-5256.2020.01.054
- VernacularTitle:急性胰腺炎与表观遗传调控机制
- Author:
Xianlin ZHAO
1
;
Shifeng ZHU
;
Hongxin KANG
Author Information
1. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
- Publication Type:Research Article
- Keywords:
pancreatitis;
DNA methylation;
histone code;
RNA, long noncoding
- From:
Journal of Clinical Hepatology
2020;36(1):227-230
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis is a local pancreatic and systemic inflammatory disease due to various living and environmental factors, such as alcohol, gallstones, high lipids, and smoking, and its pathogenesis remains unclear. Studies have shown that epigenetic regulation mechanisms, such as DNA methylation, histone modification, and non-coding RNA, play an important role in the development and progression of acute pancreatitis. This article introduces the association between the common causes of acute pancreatitis (including alcohol, gallstones, high lipids, and smoking) and epigenetic regulation mechanisms, as well as the association between inflammatory response and epigenetic regulation mechanisms. The preliminary exploration of epigenetic regulation mechanisms in acute pancreatitis provides new thoughts for further understanding the development, progression, and treatment of acute pancreatitis.
