Research advances in omega-3 polyunsaturated fatty acids in treatment of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2020.01.047
- VernacularTitle:omega-3多不饱和脂肪酸治疗非酒精性脂肪性肝病的研究进展
- Author:
Yuecheng GUO
1
;
Lungen LU
Author Information
1. Department of Gastroenterology, Shanghai General Hospital, Shanghai 200080, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
fatty acids, omega-3;
therapeutics
- From:
Journal of Clinical Hepatology
2020;36(1):198-200
- CountryChina
- Language:Chinese
-
Abstract:
With the changes in people’s lifestyle and dietary structure, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has been increasing year by year, and NAFLD has become a serious threat to human health. The treatment of NAFLD has always been a hot topic of basic and clinical research on liver diseases. In recent years, many studies have revealed that omega-3 polyunsaturated fatty acids (ω3-PUFA) can promote fatty acid oxidation, improve intestinal homeostasis, and thus improve lipid metabolism and liver inflammation, and therefore, more and more clinical studies have applied ω3-PUFA in the treatment of NAFLD. However, the mechanism of ω3-PUFA in the treatment of NAFLD is still unclear, and there are certain limitations in related clinical studies. This article mainly introduces the role of ω3-PUFA in NAFLD and the results of related clinical studies and further discusses the problems that need to be solved in ω3-PUFA for the treatment of NAFLD.
