Therapeutic experience of tacrolimus-induced pain syndrome of bilateral lower limbs after liver transplantation
10.3969/j.issn.1674-7445.2019.04.017
- VernacularTitle:肝移植术后他克莫司导致双下肢疼痛综合征的治疗经验
- Author:
Yonggen ZHENG
1
;
Lin ZHOU
;
Guosheng DU
;
Zhidong ZHU
;
Likui FENG
Author Information
1. Medical School of Chinese People's Liberation Army, Beijing 100091, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
Pain syndrome of bilateral lower limbs;
Tacrolimus;
Organ transplantation;
Alpha-fetoprotein;
Sirolimus
- From:
Organ Transplantation
2019;10(4):449-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the therapeutic experience of lower limb pain syndrome caused by tacrolimus (FK506) after liver transplantation. Methods A 52-year-old male patient diagnosed with virus B hepatitis (hepatitis B), post-hepatitis liver cirrhosis at the decompensation stage and malignant liver tumors developed bilateral lower limbs pain syndrome after liver transplantation with FK506 immunosuppressant. After eliminating the possibility of angioneurotic pain, FK506 was terminated and replaced by sirolimus (SRL) therapy. The blood concentration was maintained at 6~8 ng/mLduring the early stage, and then gradually adjusted according to the survival time of the liver graft. Results After 2-weeks conversion therapy, the swelling and pain of bilateral lower limbs of the patient were gradually relieved, and the skin pruritus was gradually healed. After 1 month, the patient was basically restored to normal activity and function. No recurrence was reported until the submission date of this manuscript. Conclusions Bilateral lower limbs pain syndrome caused by adverse reaction of FK506 is relatively rare. FK506 can be substituted by SRL to avoid the adverse reaction.
