Clinical study of value of serum Klotho level of elderly donors in predicting postoperative renal graft function in recipients
10.3969/j.issn.1674-7445.2019.04.015
- VernacularTitle:高龄供者血清Klotho水平预测受者术后移植肾功能状态的临床研究
- Author:
Jianfu WANG
1
;
Gengguo DENG
;
Chunli ZHU
;
Qin LI
;
Jiexue ZHOU
;
Shandong MENG
;
Sheng SHEN
;
Xiao WANG
;
Juan MA
;
Dong LIU
Author Information
1. Department of Organ Transplantation, Guangdong Second Provincial People's Hospital, Guangzhou 510317, China
- Publication Type:Research Article
- Keywords:
Renal transplantation;
Klotho;
Elderly donor;
Marginal donor kidney;
Renal graft function;
Serum creatinine;
Receiver operating characteristic (ROC) curve
- From:
Organ Transplantation
2019;10(4):439-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of serum Klotho level in the elderly donors to predict the renal graft function in the recipients. Methods Clinical data of 16 elderly donors and 27 recipients undergoing renal transplantation were collected. The general status of the recipients was observed. The levels of serum Klotho and serum creatinine (Scr) in the elderly donors were measured on the day of renal transplantation. The Scr levels in the recipients were measured at postoperative 1, 3 and 12 months respectively. The estimated glomerular filtration rate (eGFR) was calculated. The correlation between the serum Klotho level of the donors and postoperative graft function of the recipients was analyzed. Results The cold ischemia time during renal transplantation was (649±245) min. The incidence rate of delayed graft function (DGF) was 26%. The incidence rate of acute rejection was 7%. In the elderly donors, the serum Klotho level was 537 (245-793) pg/mL and the Scr level was (164±62) μmol/L. At postoperative 1, 3 and 12 months, the Scr levels in the recipients were (136±47), (132±43) and (133±46) μmol/L, respectively. The corresponding eGFR was (52±20), (52±19) and (53±21) mL/(min?1.73m2), respectively. The serum Klotho level in the elderly donors was negatively correlated with the renal graft function at postoperative 1 month in the recipients (P < 0.05). The sensitivity and specificity of serum Klotho level in predicting the renal graft insufficiency at postoperative 1 month were 0.909 and 0.769. Conclusions The preoperative serum Klotho level in the elderly donors have predictive value for renal graft function in the recipients at postoperative 1 month.
