An assessment of the acetone extract from the leaves of Canarium odontophyllum (Miq.) for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)
- Author:
Nur Amira Mohd Shamsuddin
1
;
Noraziah M Zin
1
;
Dayang Fredalina Basri
1
Author Information
1. Universiti Kebangsaan Malaysia
- Publication Type:Journal Article
- Keywords:
Bacteriostatic;
C. odontophyllum;
MBC;
MIC;
MRSA
- From:Malaysian Journal of Microbiology
2018;14(6):601-605
- CountryMalaysia
- Language:English
-
Abstract:
Abstract:Methicillin-resistant Staphylococcus aureus (MRSA) causes nosocomial and community infections and is a global health concern. This study evaluated the antibacterial activity of acetone extract from Canarium odontophyllum leaves against MRSA ATCC 33591 and Mu50 strains. The MIC/MBC ratio, determined using the broth micro dilution method, revealed the bacteriostatic effect of the extract against both strains. Time-kill assay against the Mu50 strain showed that the extract inhibited the growth of MRSA at low concentration but exhibited a concentration-dependent bacterial killing effect at 4× MIC. These findings confirm that an acetone extract from C. odontophyllum leaves inhibited growth of MRSA at low concentrations and could be utilised as an alternative anti-MRSA agent.
- Full text:20.2018my0495.pdf
