A new 2,3-dioxoflavonoid from the aerial part of <italic>Hypericum perforatum</italic>

VernacularTitle:贯叶金丝桃中一个新的2,3-二氧代黄酮
Author: Jie MA ¹ ; Teng-fei JI ¹ ; Jin TIAN ¹ ; Yan-gai WANG ¹ ; Jian-bo YANG ¹ ; Ya-lun SU ¹ ; Ai-guo WANG ¹
Author Information

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Publication Type:Research Article
Keywords: italic>Hypericum perforatum; chemical constituents; 2,3-dioxoflavone
From: Acta Pharmaceutica Sinica 2019;54(12):2286-2288
CountryChina
Language:Chinese
Abstract: Phytochemical study of the aerial parts of Hypericum perforatum L. resulted in the isolation of an undescribed compound, which was identified as Rel-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2-methoxy-3-(2-oxopropyl)chroman-4-one (1) by spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR spectra. Compound 1 is a new 2,3-dioxo-flavone with an acetonyl moiety, rarely found in nature. In addition, a plausible biogenetic pathway of 1 was proposed in this article.