Application of benzoxaboroles compounds in medicinal chemistry
10.16438/j.0513-4870.2019-0577
- VernacularTitle:苯并硼唑类化合物在药物化学中的应用
- Author:
Chuan WANG
1
;
Xu-ben HOU
1
;
Hao FANG
1
Author Information
1. Department of Medicinal Chemistry, School of Pharmaceutical Science, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
benzoxaboroles;
tavaborole;
crisaborole;
structure activity relationships;
biological activity
- From:
Acta Pharmaceutica Sinica
2019;54(11):1940-1948
- CountryChina
- Language:Chinese
-
Abstract:
Benzoxaborole is a series of compounds with five member ring and boron atom. Since the approval of crisaborole and tavaborole by FDA, benzoxaborole gained lots of research interests and become widely used in current drug discovery. Specially, benzoxaborole derivatives were found to exhibit anti-bacterial, anti-fungal, anti-protozoal, anti-tumor and anti-inflammatory activities. Here, we will review the properties of benzoxaborole, structure activity relationships as well as the recent progress in the biological activity of benzoxaborole derivatives.
