Anti-cancer activity of two new triterpenes from Brassica rapa
10.16438/j.0513-4870.2019-0454
- VernacularTitle:蔓菁中两个新的三萜化合物及其抗癌活性研究
- Author:
Lin DU
1
,
2
;
Qing-dong HUANG
3
;
Cong-di CHEN
1
,
2
;
Tao HAN
1
,
2
;
Qi ZHANG
1
,
2
;
Wei DU
4
Author Information
1. College of Chemistry and Life Science, Chengdu Normal University, Chengdu 611130, China
2. Institute of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
3. Chengdu Better Pharmaceutical Technology Co., Ltd., Chengdu 611130, China
4. Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- Publication Type:Research Article
- Keywords:
Tibetan material herb;
italic>Brassica rapa;
chemical constituent;
cytotoxic activity
- From:
Acta Pharmaceutica Sinica
2019;54(11):2049-2054
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents from Brassica rapa were identified by various chromatographic techniques including silica gel, reversed-phase silica gel, macroporous resin and Sephadex LH-20 column chromatography. Eight compounds were isolated from this plant. The isolated compounds were elucidated by physicochemical properties and spectroscopic methods, including extensive 1D, 2D-NMR, and HR-ESI-MS techniques. Compounds 1, 2 are new triterpenoids and 3-7 were isolated for the first time from Brassica rapa. The cytotoxic effect of compounds 1 and 2 were tested by MTT assay against five cancer cell lines. The result showed that all compounds exhibit growth inhibition for the cancer lines. Compound 1 has an IC50 value of 5.87 μmol·L-1 for growth inhibition of leukemia cell line HL-60, and IC50 value for compound 2 was 10.32 μmol·L-1.
