Modern research approaches and strategies for compatibility effects and efficacy components of herbal pairs
10.16438/j.0513-4870.2019-0413
- VernacularTitle:药对配伍效应与功效物质现代研究方法与策略
- Author:
Yu-ping TANG
1
,
2
;
Er-xin SHANG
3
;
Yan-yan CHEN
1
,
2
;
Shi-jun YUE
1
,
2
;
Xu-qin SHI
3
;
T.X. Tina DONG
4
;
W.K. Karl TSIM
4
;
Jin-ao DUAN
3
Author Information
1. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research &
2. Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China
3. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine/Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
4. Division of Life Science and Centre for Chinese Medicine, the Hongkong University of Science and Technology, Hongkong 999077, China
- Publication Type:Research Article
- Keywords:
herb pair;
compatibility effect;
efficacy component;
rug interaction;
modern research
- From:
Acta Pharmaceutica Sinica
2019;54(9):1564-1573
- CountryChina
- Language:Chinese
-
Abstract:
The herb pair is the simple and exquisite experience summary accumulated by generations of traditional Chinese medicine (TCM) experts in the process of long-term herbal prescription for curing diseases. Although it is only a combination of two herbs, it is cleverly matched and properly proportioned, which can well interpret TCM characteristics of "great combination and artful application". Moreover, the herb pair is an intermediate point between single herb and several TCM formulae, which implicates certain regularity and some connotation of many TCM formulae for diagnosis and treatment based on an overall analysis of the illness and the patient's condition. Our team has long been focusing on the complexity of drug interactions and the diversity of TCM components to carry out systematic research on herb pair by using modern scientific and technological knowledge and approaches. As results, a series of modern research approaches and strategies formed for the compatibility effect and bio-active components of the herb pair. By representing the principles and application characteristics of these approaches, this paper provides important support for elucidating scientific connotation of compatibility regularity of herb pairs and application of formulae optimization, as well as explorative ideas and approaches for modern research on other herb pairs.
