Synthesis and neuroprotective activity of resveratrol-3-n-butylphthalide hybrids
10.16438/j.0513-4870.2019-0364
- VernacularTitle:白藜芦醇-丁苯酞杂合物的合成及其神经保护活性
- Author:
Yan GAO
1
;
Wan-dong LIU
2
;
Ban-feng RUAN
1
Author Information
1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
2. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
- Publication Type:Research Article
- Keywords:
resveratrol;
italic>dl-3-n-butylphthalide;
synthesis;
neuroprotection;
PI3K/Akt
- From:
Acta Pharmaceutica Sinica
2019;54(8):1461-1469
- CountryChina
- Language:Chinese
-
Abstract:
6-Bromo-3-n-butylphthalide was obtained by nitration, reduction and diazotization from carboxybenzaldehyde. Twenty hybrids from substituted styrene and 6-bromo-3-n-butylphthalide were synthesized and the structure was confirmed by 1H NMR, 13C NMR and ESI-MS. All compounds were evaluated for neuroprotective activity against OGD/R-induced neurotoxicity in rat cortical neurons by MTT assay. The mechanism of neuroprotection was investigated by Western blot analyses. The results indicated that most of these compounds had a potent neuroprotective activity (All animal experiments were approved by the Experimental Animal Ethics Committee of Anhui University of Chinese Medicine), especially 10h and 10i showed significant effects, which may play a neuroprotective role by activating the PI3K/Akt signaling pathway.
