Research progress about the anti-aging effect and mechanism of flavonoids from traditional Chinese medicine
10.16438/j.0513-4870.2019-0283
- VernacularTitle:中药黄酮类化合物抗衰老作用及其机制研究进展
- Author:
Meng-ru LI
1
;
Yu-zhi ZHOU
1
;
Guan-hua DU
1
,
2
;
Xue-mei QIN
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
flavonoids;
antioxidant;
anti-aging;
free radical theory;
cellular signaling pathway;
metabolic pathway
- From:
Acta Pharmaceutica Sinica
2019;54(8):1382-1391
- CountryChina
- Language:Chinese
-
Abstract:
Aging is a normal physiological process involving coaction of many factors. The anti-aging effects of natural products have been studied by many domestic and international scholars, but not far enough, which still needed to be explored. Flavonoids, as natural products, have a variety of pharmacological activities and present in many traditional Chinese medicines. In recent years, research results indicate that flavonoids can delay the aging process of the nervous, immune, and reproductive systems, and the liver, skin and other tissues. The anti-aging effects of flavonoids have attracted more and more attention. Therefore, development of anti-aging drugs from flavonoids is of great significance to improve the quality of life for the elderly and slow the process of aging. However, the mechanism of the anti-aging effect of flavonoids remains unknown at present. This review will discuss the anti-aging effect and mechanisms of flavonoids in traditional Chinese medicine from the aspects of cellular signaling pathways and metabolic pathways based on the modern theories of aging.
