Energy metabolism disorder and diseases: from effects to potential targets
10.16438/j.0513-4870.2019-0161
- VernacularTitle:能量代谢紊乱对疾病的影响及其潜在药物靶点
- Author:
Bao-yue ZHANG
1
;
Ai-lin LIU
1
;
Guan-hua DU
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
energy metabolism;
rug discovery;
potential target;
neurodegenerative disease;
cancer;
metabolic disease;
cardiovascular disease
- From:
Acta Pharmaceutica Sinica
2019;54(8):1372-1381
- CountryChina
- Language:Chinese
-
Abstract:
Cellular energy metabolism disorder caused by dysfunction of nutrient utilization and mitochondrial damage contributes to a variety of diseases, including neurodegenerative diseases, cancer, metabolic diseases, and cardiovascular diseases. Understanding the effects of energy metabolism on diseases will help to improve our knowledge about disease etiology and may serve to develop strategies to delay disease progress. There are many compounds developed for targeting energy metabolism disorders, such as small molecules targeting the 18 kDa transporter (TSPO) for treatment of Alzheimer's disease, glucagon-like peptide-1 analogues for treatment of Parkinson's disease, inhibitors of glucose transporter 1 (GLUT1) and lactate dehydrogenase A for treatment of tumors, the fibroblast growth factors based treatment for type 2 diabetes (T2D), selective ligands of peroxisome proliferator-activated receptor (PPAR)-β/δ for treatment of cardiovascular diseases. We review here the abnormal energy metabolism of common energy metabolism disorder-related diseases, summarize the potential targets that may be used for new drug discovery, and the strategies for alleviating the disease process by improving energy metabolism.
