Network pharmacology-based study on mechanisms of antipyretic action of Pueraria radix
10.16438/j.0513-4870.2018-1098
- VernacularTitle:基于网络药理学葛根解热作用机制研究
- Author:
Bing-tao LI
1
;
Xing-ying ZHAI
1
;
Jia LI
2
;
Jun TU
1
;
Qi-yun ZHANG
1
;
Guo-liang XU
1
;
Li-ping HUANG
2
;
Feng SHAO
2
;
Wei-feng ZHU
2
;
Rong-hua LIU
2
Author Information
1. Research Center for Differentiation and Development of TCM Basic Theory
2. School of Pharmacy, Jiangxi University of TCM, Nanchang 330004, China
- Publication Type:Research Article
- Keywords:
Pueraria radix;
fever;
network pharmacology;
molecular docking;
biology process;
pathway analysis
- From:
Acta Pharmaceutica Sinica
2019;54(8):1409-1416
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to explore the antipyretic mechanism of Pueraria radix. The method of network pharmacology was used to determine the known ingredients corresponding to Pueraria radix, predict the drug-related gene /protein targets, and analyze the interplay between key ingredients and targets. Biological Information Annotation Databases (DAVID) was used to enrich the biological processes and pathways. The result of network analysis was validated by molecular docking. It was found that 49 active ingredients of Pueraria radix not only regulate 21 targets (e.g. PTGS2, EGFR), but also affect 11 biological processes (e.g. oxidation-reduction process, prostaglandin synthesis, positive regulation of fever generation and inflammatory response) and 7 metabolic pathways (arachidonic acid metabolism, serotonergic synapse and HIF-1, et al). Molecular docking results showed that more than 65% of the active ingredients could be well docked with key targets, and the relevant literatures indicated that the active components could inhibit the expression of PTGS2, which means the result has a high reliability. These results indicated that Pueraria radix may carry its pyretic action via a "multi-ingredients-multi-targets-multi-pathways" mode, which provides a scientific basis for further research and drug development.
