Advances in the molecular mechanism of salvianolic acid and tanshinone for intervention of diabetic kidney disease
10.16438/j.0513-4870.2018-1044
- VernacularTitle:丹酚酸和丹参酮干预糖尿病肾病的分子机制研究进展
- Author:
Qin-wen WANG
1
;
Xin-xin DAI
1
;
Xiang XIANG
1
;
Shu-lan SU
1
;
Jian-ming GUO
1
;
Yue ZHU
1
;
Da-wei QIAN
1
;
Jin-ao DUAN
1
Author Information
1. Nanjing University of Traditional Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, State Administration of Traditional Chinese Medicine, Traditional Chinese Medicine Resource Recycling, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
iabetic kidney disease;
salvianolic acid;
tanshinone;
molecular mechanisms of pharmacological action
- From:
Acta Pharmaceutica Sinica
2019;54(8):1356-1363
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease (DKD) is one of the most serious microvascular complications in diabetic patients, and is the leading cause of end-stage renal disease. The interaction between metabolic and hemodynamic factors leads to activation of the common pathways of diabetic kidney injury. Studies have shown that salvianolic acid can alleviate renal fibrosis and renal injury caused by diabetes by regulating renal tubular interstitial activator A, transforming growth factor-β1 and monocyte chemokine protein-1. It can also participate in the reconstruction of the glomerular extracellular matrix by affecting the expression of protein kinase ERK1/2 protein, which serves a protective effect on diabetic kidneys. Tanshinone can inhibit oxidative stress mediated glucose-induced kidney injury, inhibit the expression of protein tyrosine phosphatase 1B (PTP1B) activity, and improve the secretion function of beta cells in type 2 diabetes mellitus. Interstitial fibrosis in diabetic nephropathy can be alleviated by blocking TGF-β/ Smad, NF-κB and Wnt/β-catenin signaling pathway. It has been suggested that salvianolic acid and salvianone are excellent candidates for prevention and treatment of diabetic nephropathy. We provide here the scientific basis for in-depth research and development of salvianolic acid and salvianone into drugs.
