A new oleanane type triterpenoid from <italic>Viburnum taitoense</italic> Hayata

Yun-qiu WU; Yun-feng Huang; Di Luo; Li Qiu; Ji-zhao Xie; Huan-ji XU; Xin-duo WU; Zhe-ming LI

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A new oleanane type triterpenoid from Viburnum taitoense Hayata

VernacularTitle:台东荚蒾中一个新的齐墩果烷型三萜
Author: Yun-qiu WU ¹ ; Yun-feng HUANG ² ; Di LUO ¹ ; Li QIU ¹ ; Ji-zhao XIE ^{1
,

3} ; Huan-ji XU ¹ ; Xin-duo WU ¹ ; Zhe-ming LI ¹
Author Information

1. School of Pharmaceutical Science, Guangxi Medical University, Nanning 530021, China
2. Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning 530022, China
3. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China
Publication Type:Research Article
Keywords: italic>Viburnum; italic>V. taitoense Hayata; pentacyclic triterpenoid; NO; RAW264.7
From: Acta Pharmaceutica Sinica 2019;54(7):1260-1264
CountryChina
Language:Chinese
Abstract: The chemical constituents of Viburnum taitoense Hayata were investigated using column chromatography silica gel and Sephadex LH-20, etc. Seven pentacyclic triterpenoids were isolated and their structures were elucidated by spectral data and physicochemical properties as 3β,6β-dihydroxy olean-11,13(18)-dien-28-acid (1), 3β-hydroxy olean-11,13(18)-diene-28-acid (2), 12-ene-olean-28-acid-3β-palmitate (3), 3β-acetylcocodiol (4), corosolic acid (5), uvaol (6) and ursolic acid (7). Among them, compound 1 is a new oleanane type triterpenoid and its absolute configuration was confirmed by single-crystal X-ray diffraction data. Compounds 2-5 were isolated from this genus for the first time. All the compounds were evaluated for their anti-inflammatory activities in vitro, and compound 5 showed significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC₅₀ of 25.52 ± 0.56 μmol·L^-1 when compared to the positive control, quercetin (IC₅₀ of 25.46 ± 0.62 μmol·L^-1).