Recent advances in microglial activation for treatment of chronic neuropathic pain
10.16438/j.0513-4870.2018-1087
- VernacularTitle:小胶质细胞活化在慢性神经性疼痛中作用的研究进展
- Author:
Shuai SHAO
1
;
Gao-na SHI
1
;
Tian-tai ZHANG
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
noxious stimulus;
microglia;
neuroinflammation;
pain signal;
chronic neuropathic pain
- From:
Acta Pharmaceutica Sinica
2019;54(7):1166-1173
- CountryChina
- Language:Chinese
-
Abstract:
As the primary innate immune cells in the central nervous system, microglia can be activated by external noxious stimulus and in turn interact with astroglia and neurons to induce neuroinflammation and facilitate the transmission of pain signals. This response can help the central nervous system adapt to the changes of the internal environment induced by noxious stimulus, leading to the long-term sensitivity of peripheral and central pain nerve conduction pathways and chronic neuropathic pain. Numerous researches found that activation of microglia participated in the occurrence and maintenance of chronic neuropathic pain, and inhibition of microglial activation in the spinal cord or the brain had analgesic effect in animal experiments. Due to the fact that molecular and cellular mechanisms between the activation of microglia and pain remittence are unclear, there are many difficulties in designing of new drugs selectively targeting to the activation of microglia for treatment of chronic neuropathic pain. We review here the research articles on microglia and chronic neuropathic pain, sorting out the relationship between microglia and chronic neuropathic pain, and provide new ideas for the development of new drugs targeting to microglia for the treatment of chronic neuropathic pain.
