Alkaloids from an aqueous extract of Uncaria rhynchophylla
10.16438/j.0513-4870.2019-0215
- VernacularTitle:钩藤水提取物中的生物碱类成分
- Author:
Jian CAI
1
;
Qing-lan GUO
1
;
Ruo-fei LI
1
;
Yue WANG
1
;
Cheng-bo XU
1
;
Cheng-gen ZHU
1
;
Yong-chun YANG
1
;
Jian-gong SHI
1
Author Information
1. Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
Rublaceae;
Uncaria;
italic>Uncaria rhynchophylla;
aqueous extract;
monoterpene indole alkaloids;
italic>β-carboline alkaloid;
absolute configuration
- From:
Acta Pharmaceutica Sinica
2019;54(6):1075-1081
- CountryChina
- Language:Chinese
-
Abstract:
Five alkaloids were isolated from a decoction of Uncaria rhynchophylla by a combination of various chromatographic techniques, including macroporous adsorbent resin, MCI resin, silica gel, Sephadex LH-20, and reversed phase HPLC. Their structures were characterized by comprehensive analyses of spectroscopic data as monoterpene indole alkaloids (+)-(7R)-3-oxo-7-hydroxy-3,7-seco-dihydrorhynchohylline (1), (+)-(7S)-3-oxo-7-hydroxy-3,7-seco-dihydrorhyncho-hylline (2), (+)-(7R)-3-oxo-7-hydroxy-3,7-seco-rhynchohylline (3) and (+)-(7S)-3-oxo-7-hydroxy-3,7-seco-rhynchohylline (4), and a β-carboline alkaloid 1,2,3,4-tetrahydro-1-oxo-β-carboline (5). Among them, 1 and 2 are new compounds, 3 and 4 are new natural products that were semi-synthesized from isorhynchohylline with incorrect specific rotations, and 5 is isolated for the first time from the genus Uncaria.
