2018 DMPK research progress in China
10.16438/j.0513-4870.2019-0138
- VernacularTitle:2018年中国药物代谢研究进展
- Author:
Lu-shan YU
1
;
Hui-chang BI
2
;
Bao-jian WU
3
;
Guang-bo GE
4
;
Jiang ZHENG
5
,
6
;
Hai-ling QIAO
7
;
Su ZENG
1
Author Information
1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
3. School of Pharmacy, Jinan University, Guangzhou 510632, China
4. Institute of Interdisciplinary Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
5. Shenyang Pharmaceutical University, Shenyang 110016, China
6. School of Pharmacy, Guizhou Medical University, Guiyang 550004, China
7. Basic Medical College, Zhengzhou University, Zhengzhou 450001, China
- Publication Type:Research Article
- Keywords:
rug metabolism;
rug metabolic enzymes;
rug transporters;
regulation mechanism
- From:
Acta Pharmaceutica Sinica
2019;54(6):963-970
- CountryChina
- Language:Chinese
-
Abstract:
This paper summarizes research progresses of Chinese scholars in the field of drug metabolism and pharmacokinetics (DMPK) in 2018. Chinese scholars focused on drug metabolizing enzymes and transporters, and carried out studies on the mechanisms of drug metabolism and transport of active molecules. Topics of research included regulatory mechanisms of drug metabolizing enzymes or transporters, and their implications in drug development and disease etiology or progression. Here, we summarized studies on drug toxicity based on drug metabolism or transport, rational drug use in the clinic, drug metabolism mediated by intestinal flora, metabolism of traditional Chinese medicines, and new technologies or models in DMPK. In recent years, the research focus of drug metabolism in China has transformed from serving for new drug discovery and rational use, to innovation driven and mechanism oriented research. The domestic research topics and technology utilization are gradually aligning with the international conventions.
