Research progress of drug delivery system with

VernacularTitle:门控型药物递送系统研究进展
Author: Jia ZHANG ¹ ; Ting ZHAO ¹ ; Jie-ning DUN ¹ ; Ming-xian SUN ¹ ; Rong-rong HUANG ¹ ; Bai XIANG ¹ ; Jing BAI ² ; De-ying CAO ¹
Author Information

1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
2. Department of Pharmacy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Publication Type:Research Article
Keywords: gatekeeper; rug delivery system; microenvironment; stimuli-responsive; tumor therapy
From: Acta Pharmaceutica Sinica 2019;54(6):1017-1025
CountryChina
Language:Chinese
Abstract: The drug delivery system with "gatekeeper" is designed to achieve a stable entrapment state of the payload under normal physiological conditions through the gatekeepers. With tumor microenvironment or stimulation of exogenous factors, the gatekeeper is detached or altered to promote the responsive release of the drug. In this paper, we focus on applications of stimuli-responsive linkages and stimuli-responsive groups, and review research progresses of drug delivery system with "gatekeeper" developed over the past 10 years.