The progress in the development of HIV inhibitors targeting protein-protein interactions
10.16438/j.0513-4870.2019-0050
- VernacularTitle:以蛋白质-蛋白质相互作用为靶点的HIV抑制剂的研究进展
- Author:
Zhao WANG
1
;
Desta SAMUEL
1
;
Dong-wei KANG
1
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
AIDS;
HIV;
protein-protein interaction;
inhibitor
- From:
Acta Pharmaceutica Sinica
2019;54(4):620-628
- CountryChina
- Language:Chinese
-
Abstract:
Protein-protein interaction (PPI) plays an important role in many steps of the human immunodeficiency virus (HIV) life cycle. Targeting these protein-protein interactions, especially the interaction between the virus with host cells, can provide new insights into the development of HIV inhibitors with novel mechanisms of action. Herein, we review the latest discoveries of PPI inhibitors based on the mechanisms of action of various protein-protein interactions with specific research examples.
