A new strategy to intervene tumor metabolism: regulatory targets for amino acid metabolism and advances in drug research
10.16438/j.0513-4870.2018-0969
- VernacularTitle:干预肿瘤代谢的新策略: 氨基酸代谢的调控途径及其药物研究进展
- Author:
Hong-li JIANG
1
;
Xue-yang JIANG
1
;
Tong-zhong TANG
1
;
Wen-yuan LIU
2
;
Feng FENG
1
;
Hao-peng SUN
3
;
Wei QU
1
Author Information
1. School of Traditional Chinese Pharmacy
2. Department of Pharmaceutical Analysis
3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210000, China
- Publication Type:Research Article
- Keywords:
amino acid metabolism;
cancer;
glutamine;
serine;
tryptophan;
metabolic pathway;
active molecular
- From:
Acta Pharmaceutica Sinica
2019;54(3):407-419
- CountryChina
- Language:Chinese
-
Abstract:
Reprogramming of metabolism is one of the most critical features in tumorigenesis and tumor growth. Many types of cancer show an increased demand for specific amino acids, rely on exogenous supplies, or alter amino acid metabolic pathways, leading to changes in corresponding amino acid levels to meet the need of tumorigenesis. Therefore, if the level of tumor growth-dependent amino acids can be effectively controlled, a new treatment strategy can be developed from the perspective of cell metabolism. At present, remarkable progress has been made in this field. This paper outlines the amino acid metabolic pathways closely related to tumorigenesis and tumor growth, and summarizes the corresponding regulatory mechanisms and active molecules. Finally, the direction of the field is discussed and prospected for future development.
