Mechanisms of ferroptosis and its involvement in Parkinson's disease
10.16438/j.0513-4870.2018-0966
- VernacularTitle:铁死亡调控机制及其在帕金森病中的研究进展
- Author:
Zhe ZHAO
1
;
Xiu-qi BAO
1
;
Dan ZHANG
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Natural Products and Functions, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
ferroptosis;
Parkinson's disease;
iron metabolism;
reduced glutathione;
lipid peroxidation
- From:
Acta Pharmaceutica Sinica
2019;54(3):399-406
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel type of regulated cell death with morphology, biochemistry and mechanisms differing from traditional cell death types such as apoptosis, necrosis and pyroptosis. The regulatory mechanisms of ferroptosis mainly involve iron metabolism, amino acid metabolism and lipid metabolism. It has been found that ferroptosis plays a key role in the pathogenesis of diseases including neurodegenerative diseases, malignant tumors and ischemic reperfusion injury. Parkinson's disease (PD) is one of the most common neurodegenerative diseases and its etiology and pathogenesis remains unclear. Recent studies revealed that ferroptosis might be involved in the pathogenesis of PD, as evidenced by high iron content, depletion of reduced form of glutathione and elevated levels of lipid peroxides detectable in the midbrain of PD patients. Both in vitro and in vivo models of PD have shown that some ferroptosis inhibitors have the ability of attenuating the symptoms and one iron chelator is undergoing a clinic trial. We here summarize the mechanisms of ferroptosis and its association with PD, in an effort to suggest potential novel targets for therapies of PD.
