Progress in the study of the association between the lipid droplets and hepatitis C virus life cycle
10.16438/j.0513-4870.2018-0867
- VernacularTitle:脂滴代谢与丙型肝炎病毒生活周期关联的研究进展
- Author:
Ni AN
1
;
Dong-rong YI
1
;
Xiao-yu LI
1
;
Shan CEN
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
lipid droplet;
hepatitis C virus;
lipid metabolism;
flaviviridae;
lipid droplets-associated protein
- From:
Acta Pharmaceutica Sinica
2019;54(3):393-398
- CountryChina
- Language:Chinese
-
Abstract:
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis and production of essential lipid-derived molecules. There is increasing evidence that hepatitis C virus (HCV) has co-evolved due to its lack of lipid biosynthetic pathways to utilize host lipid metabolic pathways to establish a suitable environment for virus proliferation and obtain the necessary components, eventually promote the assembly and transportation of virus. In this review, we outline the relationship between HCV life cycle and lipid droplet biosynthesis and metabolism, with the aim to discover potential antiviral targets for development of new therapeutic interventions.
