Anti-inflammatory activity of two new sesquiterpenoids from Radix Angelicae Pubescentis

VernacularTitle:独活中的两个新倍半萜化合物及其抗炎活性研究
Author: Ming LI ^{1
,

2} ; Jian-hui WEN ^{1
,

2} ; Fu-yong NI ^{1
,

2} ; Xue XIE ^{1
,

2} ; Yun WU ^{1
,

2} ; Zhen-zhong WANG ^{1
,

2} ; Wei XIAO ^{1
,

2}
Author Information

1. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China
Publication Type:Research Article
Keywords: Radix Angelicae Pubescentis; chemical constituent; structure determination; anti-inflammatory activity
From: Acta Pharmaceutica Sinica 2019;54(2):343-347
CountryChina
Language:Chinese
Abstract: Chemical constituents from the ethanol extract of Radix Angelicae Pubescentis was isolated and purified through Diaion HP-20 macroporous, silica gel column chromatography, gel filtration over Sephadex LH-20 and preparative HPLC. Two new sesquiterpenoid derivatives were identified as angesesquid A (1) and angesesquid B (2), and their structures were determined. In vitro degeneration model of primary rat disc chondrocytes was used to evaluate the anti-inflammatory activity of these two compounds. The results showed that compounds 1 and 2 had no anti-proliferation effect. Both compounds inhibited the release of NO, but had no inhibitory activity for the release of PGE₂. This finding implies that both of these two new sesquiterpenoids could moderately inhibit the inflammatory reaction to some extent.