A hypothesis on the Q-markers based on characteristics of opposite-effect of herbs: an example of Sanqi
10.16438/j.0513-4870.2018-0824
- VernacularTitle:基于反向功效差异性特点的中药质量标志物研究思路—以三七为例
- Author:
Xiao-tao HOU
1
,
2
,
3
;
Er-wei HAO
3
,
4
,
5
;
Zheng-cai DU
3
,
4
,
5
;
Zhong-shang XIA
1
;
Jia-gang DENG
3
,
4
;
Tie-jun ZHANG
6
;
Chang-xiao LIU
6
Author Information
1. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China
2. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning 530200, China
3. Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning 530200, China
4. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning 530200, China
5. Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
6. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
- Publication Type:Research Article
- Keywords:
opposite-effect;
Q-marker;
Sanqi;
strategies and approaches
- From:
Acta Pharmaceutica Sinica
2019;54(2):211-221
- CountryChina
- Language:Chinese
-
Abstract:
The quality definition of traditional Chinese medicine (TCM) is a hot area in modern research of TCM. In recent years, the characteristics of one herb with multiple effects have been widely accepted and studied. The typical opposite-effect of herbs is considered as a special part of one herb with multiple effects, and was summarized in this paper. Sanqi was used as an example of opposite-effect herbs for developing the strategies and approaches on the Q-markers. The traditional opposite-effect should be studied by modern pharmacological research methods. The correlation of the chemical components with the opposite effects should be established in order to verify the material basis and evaluate the mechanism including targets and pathways. The unique characteristics of chemical components should be analyzed and defined. Finally, the Q-markers of the opposite effect herb will be confirmed. This paper provides a useful reference for the precise quality control of herbal opposite-effects.
