Discovery of quality markers of traditional Chinese medicine compounds and visualization technology of content-effect colour atla
10.16438/j.0513-4870.2018-0775
- VernacularTitle:复方中药质量标志物的发现与量效色卡可视化技术
- Author:
Xian-sheng MENG
1
,
2
,
3
;
Yong-rui BAO
1
,
2
,
3
;
Shuai WANG
1
,
2
,
3
;
Tian-jiao LI
1
,
2
,
3
;
Guo-an LUO
4
Author Information
1. School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
2. Province Multi-Component Chinese Medicine Engineering Technology Research Center of Liaoning, Dalian 116600, China
3. Modern Traditional Chinese Medicine Research and Engineering Laboratory of Liaoning, Dalian 116600, China
4. Department of Chemistry, Tsinghua University, Beijing 100084, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine compound;
quality marker;
spectrum-effect relationship;
content- effect colour atla
- From:
Acta Pharmaceutica Sinica
2019;54(2):222-227
- CountryChina
- Language:Chinese
-
Abstract:
The chemical composition of traditional Chinese medicine (TCM) compounds is complex, the treatment is broad, and the quality control indexes cannot accurately reflect the functional properties. According to the above problems, the authors take the research process of quality markers of Qizhiweitong granules as an example to innovate the research ideas and technical methods, and constructed five progressive steps of TCM compounds quality control and evaluation model: "based on function, to figure out the attending", "components and pharmacodynamics correlation, multiple components with multiple effects", "to analyze the components, and systematically integrate them", "spectrum and effect correlation, from a spectrum to see the efficiency", and "from the content-effect colour atla to see the quality". Based on the multiple effects of components, multiple components of multi-effect pharmacological efficacy evaluation system were established. All-time isobaric multiwavelength fusion fingerprint technology was improved and developed. "Spectrum-effect colour atla" software was research and developed for the first time, to realize the "visualization" of TCM efficacy. The aim of this work is to provide an exploratory solution for the integrated quality control of TCM compounds.
