Applications of ionic liquids in drug research
10.16438/j.0513-4870.2018-0761
- VernacularTitle:离子液体在药物研究中的应用
- Author:
Jian-ping CAO
1
;
Yong-xiao MOU
1
;
Yuan-yuan CHEN
1
;
Tao WEI
1
;
Chao-jie WANG
1
Author Information
1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
- Publication Type:Research Article
- Keywords:
ionic liquid;
rug synthesis;
rug delivery;
active pharmaceutical ingredient;
clinical application
- From:
Acta Pharmaceutica Sinica
2019;54(2):245-257
- CountryChina
- Language:Chinese
-
Abstract:
Ionic liquids are not limited to the traditional use of solvents because of their high permeability and excellent physicochemical and unique biological properties. Nowadays, with the deep understanding of their toxicity and biocompatibility, ionic liquids have been tailored as novel solutions to address potential problems of marketed drugs. Based on the research and development of modified new drugs, ionic liquids have been incorporated into drug synthesis and emerged as attractive environmental-friendly reaction media with milder reaction conditions, higher yields and easier reaction workups and drug delivery systems. In addition, they have been designed for effective drug carriers removing undesirable properties of solid drugs. Further, ionic liquids forming active pharmaceutical ingredients dedicated to the liquefaction of drugs for promising clinical applications.
