Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology
10.16438/j.0513-4870.2018-0600
- VernacularTitle:牛磺鹅去氧胆酸抗炎作用机制的网络药理学研究
- Author:
Lei LI
1
;
Ba-ya-er TUMEN
2
;
Pei-feng LI
3
;
Chang LIU
1
;
Sheng-he LI
1
;
Kang-jian NING
1
;
Jin-peng JIANG
1
Author Information
1. Key Laboratory of Quality and Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China
2. Shanxi Animal Disease Control Center, Taiyuan 030027, China
3. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture and Rual, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
taurochenodeoxycholic acid;
inflammation;
network pharmacology;
pharmacological mechanism;
molecular docking
- From:
Acta Pharmaceutica Sinica
2018;53(12):2064-2075
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the anti-inflammatory mechanisms of taurochenodeoxycholic acid (TCDCA), the molecule structure file of TCDCA was downloaded from PubChem database, PharmMapper and GeneCards were used to predict and screen the targets of TCDCA. STRING database and Cytoscape software were used to construct protein interactions network. GO and KEGG analysis was preformed through STRING database. The key targets were validated by molecular docking and the targets type was attributed by DisGeNET database. The network showed that 89 targets were involved in 68 biological processes including response to stimulus, multicellular organismal process, single-multicellular organism process, response to chemical, response to organic substance, by adjusting 51 signaling pathways, such as pathways in cancer, progesterone-mediated oocyte maturation, MAPK signaling pathway, proteoglycans in cancer. These findings provide an overview of anti-inflammation of TCDCA, which reflects the characteristic of multi-targets and multi-pathways of TCDCA. It pointed out the direction for further research on anti-inflammatory mechanism of TCDCA.
