Molecular mechanism of heat-clearing and detoxifying efficacy of Forsythia suspensa based on network pharmacology
10.16438/j.0513-4870.2018-0577
- VernacularTitle:基于网络药理学连翘清热解毒功效的分子机制研究
- Author:
Xia SHEN
1
;
Rong-rong XU
1
;
Li-shan PEI
1
;
Cong'e TAN
1
;
Jun XU
2
;
Yong-gang YAN
1
Author Information
1. School of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
2. Department of Modern Chinese Medicine, Tianjin Pharmaceutical Research Institute, Tianjin 300193, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
network pharmacology;
Forsythia suspensa;
detoxification;
material basis;
molecular mechanism
- From:
Acta Pharmaceutica Sinica
2018;53(11):1834-1842
- CountryChina
- Language:Chinese
-
Abstract:
Forsythia suspensa is a herbal medicine that widely used for heat-clearing and detoxification in clinical practice. However, the molecular mechanism of its heat-clearing and detoxifying effect is still unclear. Based on the theory and methods of network pharmacology, the efficacy of the heat-clearing and detoxification of Forsythia suspensa was analyzed in this study. A total of 114 of compounds in Forsythia suspensa were collected, and 15 of effective compounds were obtained by analyzing the bioavailability (OB) and drug-like properties (DL). Then 26 corresponding targets were obtained using reverse pharmacophore-docking method. Using the BioGPS database, the organ location of the target initially was revealed. The compound-targetdisease network model of Forsythia suspensa was constructed by using the Cytoscape, which showed that the material basis of the heat-clearing and detoxification of Forsythia suspensa was to synthesize and synergize the effects by combining various active ingredients of multiple targets, simultaneously. This study explains the scientific mechanism of the heat-clearing and detoxification of Forsythia suspensa, and provides a theoretical foundation for clinical rational usage of Forsythia suspensa.
