The current application of stem cell based therapy in pulmonary hypertension
10.16438/j.0513-4870.2018-0347
- VernacularTitle:肺动脉高压的干细胞治疗研究进展
- Author:
Ding ZHANG
1
;
Jun YANG
1
Author Information
1. Department of Cell Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
pulmonary hypertension;
stem/progenitor cells;
cell therapy;
vascular remodeling
- From:
Acta Pharmaceutica Sinica
2018;53(11):1778-1783
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with high mortality and increased prevalence. The target therapy of pulmonary hypertension is mainly dependent on vasodilation, but how to improve vascular remodeling with stem cell therapy has not been fully understood. Over the past ten years, the researches on endothelial progenitor cells, mesenchymal stem cells and pluripotent cells have brought the hope to patients with pulmonary hypertension. This article mainly introduces the latest progress of stem cell technology in the intervention of pulmonary hypertension, and discusses the problems in the application.
