Macrophage migration inhibitory factor, a critical link between inflammation and cancer
10.16438/j.0513-4870.2018-0530
- VernacularTitle:巨噬细胞迁移抑制因子,连接炎症和肿瘤的关键蛋白
- Author:
Dan-dan ZHOU
1
;
Jiao-jiao YU
1
;
Fang HUA
1
;
Zhuo-wei HU
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150), Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
macrophage migration inhibitory factor;
inflammation;
tumor;
tumor microenvironment;
targeted therapy
- From:
Acta Pharmaceutica Sinica
2018;53(11):1761-1769
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage migration inhibitory factor (MIF) is a classical pro-inflammatory cytokine that plays an important role in the innate and adaptive immune regulation. In recent years, a large number of studies have demonstrated that the expression level of MIF is significantly increased in a variety of tumor tissues and MIF promotes the occurrence and development of tumors. MIF participates in the regulation of tumor growth, metastasis, angiogenesis, as well as induces and maintains the tumor microenvironment. Targeting MIF has been considered as a candidate strategy against cancer. In this review, the structural features, the signaling pathway, the biological functions of MIF are briefly outlined. Moreover, approaches that target MIF in the treatment of cancer are also summarized.
