Mechanism of detoxification of Chebulae Fructus against Aconiti kusnezoffii radix toxicity based on network pharmacology
10.16438/j.0513-4870.2018-0506
- VernacularTitle:基于网络药理学探讨蒙药诃子解草乌心脏毒的机制研究
- Author:
Jian-liang LI
1
;
Hui LIANG
2
;
Shu-zhen CAI
3
;
Zhi-yong LI
4
;
Ya TU
5
Author Information
1. Medical Research Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China
2. Mongolian Medicine College, Inner Mongolia Medical University, Huhehaote 010110, China
3. Mongolian Medicine College, Inner Mongolia University of Nationalities, Tongliao 028000, China
4. Pharmacy College of Minzu University of China, Beijing 100081, China
5. Development Research Center of TCM, China Academy of Traditional Chinese Medicine, Beijing 100700, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Chebulae Fructus;
Aconiti kusnezoffii radix toxicity;
Mongolian medical theory;
network pharmacology;
mechanism
- From:
Acta Pharmaceutica Sinica
2018;53(10):1670-1679
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of detoxification of Chebulae Fructus against Aconiti kusnezoffii radix toxicity, which was known as Mongolian medical theory, was studied by establishing network of active components-targets-pathways of detoxification and enrichment analysis of targets and pathways based on network pharmacology. Firstly, the targets of active components collected from TCMSP and TCM Database@Taiwan were obtained through SwissTargetPrediction compared with disease targets from OMIM, TTD, DiGSeE. Then, the target enrichment analysis of GO functional annotations and KEGG pathways and protein function were analyzed by Metascape, furthermore, the action between main active ingredients and targets was assessed by SystemsDock Web Site. At last, the Cytoscape was used to construct the network of active components-targets-pathways. In conclusion, there were 15 components and 40 targets related to the cardiotoxicity caused by Aconiti kusnezoffii radix. Furthermore, Chebulae Fructus could regulate cardiac function to detoxify the toxicity by Aconiti kusnezoffii radix through the biological process of negative regulation of blood vessel diameter, regulation of ion transport circulatory system process, muscle contraction inorganic ion homeostasis and the pathways of neuroactive ligand-receptor interaction, calcium signaling pathway, adrenergic signaling in cardiomyocytes, etc.
